Intracerebral electrical stimulations of the temporal lobe: A stereoelectroencephalography study

The functional anatomy of the anteromesial portion temporal lobe and its involvement in epilepsy can be explored by means intracerebral electrical stimulations. Here, we aimed to expand knowledge physiological pathophysiological symptoms conducting first large-sample systematic analysis 1529 stimulations this anatomical region. We retrospectively analysed all clinical manifestations induced 173 patients with drug-resistant focal at least one electrode implanted area. found that high-frequency were more likely evoke electroclinical (p < .0001) also provoked ‘false positive’ seizures. Multimodal associated EEG modification (after discharge) .0001). Visual not after discharge = .0002) mainly evoked stimulation hippocampus .009) parahippocampal gyrus .0212). ‘False positive seizures’ hippocampus, amygdala, due their intrinsic low epileptogenic threshold. gyrus, without changes, are suggest these areas visual ventral stream. Our findings provide meaningful guidance interpretation intracranial studies lobe.